Back to Search Start Over

Thermal effects in the organocatalytic asymmetric Mannich reaction

Authors :
Rodriguez, Belen
Bolm, Carsten
Source :
Journal of Organic Chemistry. March 31, 2006, Vol. 71 Issue 7, p2888, 4 p.
Publication Year :
2006

Abstract

The proline-catalyzed direct asymmetric Mannich reaction between cyclohexanone, formaldehyde, and various anilines is thermally accelerated. With only 0.5 mol % of catalyst, Mannich products with up to 98% ee are obtained after a short period of time in reactions performed under microwave irradiation.

Subjects

Subjects :
Aniline -- Chemical properties
Aniline -- Thermal properties
Formaldehyde -- Chemical properties
Formaldehyde -- Thermal properties
Proline -- Chemical properties
Catalysis -- Analysis
Biological sciences
Chemistry

Details

Language :
English
ISSN :
00223263
Volume :
71
Issue :
7
Database :
Gale General OneFile
Journal :
Journal of Organic Chemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.147643342

Tools

Authors Abstract Subjects Details