Airway smooth muscle prostaglandin-[EP.sub.1] receptors directly modulate [β.sub.2]-adrenergic receptors within a unique heterodimeric complex

Authors :: McGraw, Dennis W.
Mihlbachler, Kathryn A.
Schwarb, Mary Rose
Rahman, Fahema F.
Small, Kersten M.
Almoosa, Khalid F.
Liggett, Stephen B.
Source :: Journal of Clinical Investigation. May 2006, Vol. 116 Issue 5, p1400, 10 p.
Publication Year :: 2006
Abstract: Multiple and paradoxical effects of airway smooth muscle (ASM) 7-transmembrane-spanning receptors activated during asthma, or by treatment with bronchodilators such as [β.sub.2]-adrenergic receptor ([β.sub.2]AR) agonists, indicate extensive receptor crosstalk. We [...]

Subjects :: Research
Adrenergic receptors -- Research
Prostaglandins -- Research
Medical research
Asthma -- Research
Medicine, Experimental
Epinephrine -- Receptors

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