Opposite stereoselective resistance to digestion by phosphodiesterases I and II of benzo/a~pyrene diol epoxide-modified oligonucleotide adducts

Authors :: Bing Mao
Bin Li
Amin, Shantu
Cosman, Monique
Geacintov, Nicholas E.
Source :: Biochemistry. Nov 9, 1993, Vol. 32 Issue 44, p11785, 9 p.
Publication Year :: 1993
Abstract: Altered DNA reveals two lesions, (+)-trans-anti-BPDE-N2-dG and (-)-trans-anti-BPDE-N2-dG which are the mononucleotide trans incorporation of two anti-BPDE enantiomers. The lesions reveal variations in enzymatic processing which are determined by basic exonucleases. The working of direction-responsive enzymes are influenced in various ways by organizations of bulky pyrenyl residues.

Subjects :: Phosphodiesterases -- Research
Digestion -- Analysis
Nucleotides -- Analysis
Benzopyrene -- Research
Biological sciences
Chemistry

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