The model calmodulin-binding peptide melittin inhibits phosphorylase kinase by interacting with its catalytic center

Calmodulin reveals high levels of attraction for melittin, which can be bound by the four subunits of phosphorylase kinase. The reaction between melittin and the catalytic gamma-subunit of the enzyme results in the important inactivation of the phosphorylase kinase holoenzyme. Potential autoregulation of the enzyme depends on the varying distinction of calmodulin-binding peptides. Reaction with the delta-subunit can cause negligible inactivation by melittin.