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The model calmodulin-binding peptide melittin inhibits phosphorylase kinase by interacting with its catalytic center
- Source :
- Biochemistry. Nov 9, 1993, Vol. 32 Issue 44, p11865, 8 p.
- Publication Year :
- 1993
-
Abstract
- Calmodulin reveals high levels of attraction for melittin, which can be bound by the four subunits of phosphorylase kinase. The reaction between melittin and the catalytic gamma-subunit of the enzyme results in the important inactivation of the phosphorylase kinase holoenzyme. Potential autoregulation of the enzyme depends on the varying distinction of calmodulin-binding peptides. Reaction with the delta-subunit can cause negligible inactivation by melittin.
Details
- ISSN :
- 00062960
- Volume :
- 32
- Issue :
- 44
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.14832125