GLUT-4 content in plasma membrane of muscle from patients with non-insulin-dependent diabetes mellitus

An analysis of the constitution of immunoreactive GLUT-4 protein, contained in the plasma membrane of skeletal muscle from patients with non-insulin-dependent diabetes mellitus (NIDDM), revealed the consistency between plasma membrane composition of GLUT-4 protein from NIDDM patients and that from normal subjects. Application of subcellular fractionation technique to human muscle biopsies, performed at the basal level, failed to define the effect of insulin on plasma membrane composition of GLUT-4 protein in human muscle.