Autoregulation of histamine synthesis through H3 receptors in isolated fundic mucosal cells

An analysis of histamine-regulated histidine decarboxylase activity in samples of rabbit gastric mucosal cells, incorporated with mucous and endocrine cells, revealed the role of histamine during negative regulation of histamine synthesis. This downregulation involves a pathway featuring induction of autoreceptors which possess pharmacological properties, similar to those of H3 receptors. Mucosal cells, pre-treated with thioperamide, released large quantities of histamine during experiments performed on fraction F1 population of histamine-secreting cells from rabbit gastric mucosa.