Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: A pilot study

A study was conducted to determine if the variation in genes of pharmacological interest were associated with the pharmacokinetic and pharmacodynanic profile of indinavir (IDV), zidovudine (ZDV), and lamivudine. Results revealed that the novel relationships were identified among genetic variants in drug transporters and indinavir, lamivudine-triphosphate, and zidovudine-triphosphate concentrations.