The molecular-properties-based approach to understanding PDZ domain proteins and PDZ ligands

The existence of a significant level of co-regulation between PDZ domain-encoding genes and PDZ domain ligand interactions was discovered embedded in a large scale expression data set. This discovery leads to show how integration of expression data, a comparative genomics catalog of 899 mammalian genes with conserved PDZ-binding motifs, phylogenetic analysis and literature mining can be utilized to infer PDZ complexes.