Synthesis and stereochemistry of the antitumor diterpenoid (+)-zerumin

The first synthesis of zerumin B is achieved by a concise, highly efficient pathway featuring stereoselective addition of a new silyloxyfuryltitanium reagent to an aldehyde intermediate and silyloxyfuran oxyfunctionalization as key steps. The synthesis of (+)-zerumin B has established a relative and absolute configuration of zerumin B along with its identity with a new isolated from the plant Renealmia alpinia.