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Solution structure of a GA mismatch DNA sequence, d(CCATGAATGG)2, determined by 2D NMR and structural refinement methods
- Source :
- Biochemistry. Feb 8, 1994, Vol. 33 Issue 5, p1053, 10 p.
- Publication Year :
- 1994
-
Abstract
- A multinuclear NMR analysis and molecular refinement study of a 5-pyrimidine-GA-purine-3' sequence molecular model reveals the presence of a B-type right-handed helix, with the constituent bases possessing routine anti-glycosidic torsional angles. Type I mismatched bases possess edge-to-face hydrogen bonds while type II base pairs have face-to-face hydrogen bonds. The flanking sequences determine the conformation with 5'-pyrimidine-GA-purine-3' sequences which select type I conformation and the 5'-purine-GA-pyrimidine-3' sequences having type II conformation.
- Subjects :
- Purines -- Models
Pyrimidines -- Models
Biological sciences
Chemistry
Subjects
Details
- ISSN :
- 00062960
- Volume :
- 33
- Issue :
- 5
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.15275998