Human pregnane X receptor: genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activity

Authors :: He, Ping
Court, Michael H.
Greenblatt, David J.
von Moltke, Lisa L.
Source :: Journal of Clinical Pharmacology. November 2006, Vol. 46 Issue 11, p1356, 14 p.
Publication Year :: 2006
Abstract: Human pregnane X receptor (hPXR) gene polymorphisms (spanning exon 2 to exon 5) and alternative mRNA splicing were investigated as possible contributors to individual variability in CYP3A metabolic activity measured [...]

Subjects :: Genetic variation -- Research
Genetic engineering -- Research
Reverse transcriptase -- Research
Pharmacogenetics -- Research
Health
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