C-glycoside clustering on calix[4]arene, adamantane, and benzene scaffolds through 1,2,3-triazole linkers

An experiment was conducted to develop an alkyne-azide cycloaddition based route to various C-glycoclusters featuring 1,2,3-triazole rings as linkers and different scaffolds. Each cycloaddition occurred with high regio-selectivity to give exclusively the 1,4-disubstituted triazole ring in very high yield up to an average value of 98%.