DHEA in elderly women and DHEA or testosterone in elderly men

A 2-year, randomized, placebo-controlled, double-blind study is conducted to determine the effects of full dehydroepiandrosterone (DHEA) replacement and low-dose testosterone replacement on body composition, physical performance, bone mineral density (BMD) and glucose tolerance in elderly people with low androgen levels. The results have shown that neither DHEA nor low-dose testosterone replacement in elderly people has physiologically relevant effects on body composition, physical performance, insulin sensitivity or quality of life.