Matrix metalloproteinase and elastase activities in LPS-induced acute lung injury in guinea pigs

Authors :: D'Ortho, M.-P.
Jarreau, P.-H.
Delacourt, C.
Macquin-Mavier, I.
Levame, M.
Pezet, S.
Harf, A.
Lafuma, C.
Source :: The American Journal of Physiology. March, 1994, Vol. 266 Issue 3, pL209, 8 p.
Publication Year :: 1994
Abstract: Studies on guinea pigs with lung injury reveal that inflammatory cells inhibit increased total gelatinase activity. The matrix metalloproteinases are involved in the alveocapillary barrier lesions. Most of the gelatinases and neutrophils are present as zymogens. Oxidant stress may further enhance the process causing higher free enzymatic activity.

Subjects :: Acute respiratory distress syndrome -- Analysis
Endotoxins -- Physiological aspects
Bronchoalveolar lavage -- Analysis
Biological sciences

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