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A structural basis for the chiral preferences of lipases
- Source :
- Journal of the American Chemical Society. April 20, 1994, Vol. 116 Issue 8, p3180, 7 p.
- Publication Year :
- 1994
-
Abstract
- X-ray crystallography was used to determine the mechanism by which lipase from Candida rugosa differentiates between enantiomers of menthol. This mechanism may elucidate the structural features in lipases that are associated with enantiorecognition. Phosphonates were covalently linked to the active site serene to imitate the transition state for menthyl ester hydrolysis.
- Subjects :
- Lipase -- Research
Chirality -- Research
Chemistry
Subjects
Details
- ISSN :
- 00027863
- Volume :
- 116
- Issue :
- 8
- Database :
- Gale General OneFile
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.15504221