Kruppel-associated boxes are potent transcriptional repression domains

Authors :: Margolin, Judith F.
Friedman, Josh R.
Meyer, Wolfram K.-H.
Vissing, Henrik
Thiesen, Hens-Jurgen
Rauscher, Frank J., III
Source :: Proceedings of the National Academy of Sciences of the United States. May 10, 1994, Vol. 91 Issue 10, p4509, 5 p.
Publication Year :: 1994
Abstract: The Kruppel-associated box (KRAB) when fused to a heterologous DNA-binding domain from the yeast GAL4 protein, behaves as a DNA binding-dependent transcriptional repressor. The KRAB domain is found in the amino-terminal regions of several Kruppel-class Cys2His2 zinc finger proteins. KRAB is a conserved 75-aa region with two amphipathic alpha-helices.

Subjects :: Genetic transcription -- Regulation
Amino acid sequence -- Analysis
Science and technology

ISSN :: 00278424
Volume :: 91
Issue :: 10
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.15535017

Tools