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Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: A randomized controlled trial

Authors :
Marks, Leonard S.; Mazer, Norman A.
Mostaghel, Elahe; Hess, David L.
Dorey, Frederick J.; Epstein, Jonathan I.
Veltri, Robert W.; Makarov, Danil V.; Partin, Alan W.
Bostwick, David G.; Macairan, Maria Luz; Nelson, Peter S.
Source :
JAMA, The Journal of the American Medical Association. Nov 15, 2006, Vol. 296 Issue 19, p2351, 11 p.
Publication Year :
2006

Abstract

A randomized controlled trial is conducted to determine the effects of testosterone replacement therapy (TRT) on prostate tissue of ageing men with low serum testosterone levels. The preliminary results have shown that in aging men with late-onset hypogonadism, six months of TRT normalizes serum androgen levels but appears to have little effect on prostate tissue androgen levels and cellular functions.

Details

Language :
English
ISSN :
00987484
Volume :
296
Issue :
19
Database :
Gale General OneFile
Journal :
JAMA, The Journal of the American Medical Association
Publication Type :
Academic Journal
Accession number :
edsgcl.155994685