Extended thiopurine metabolite assessment during 6-thioguanine therapy for immunomodulation in Crohn's disease

Authors :: de Boer, N.K.H.
Derijks, L.J.J.
Keizer-Garritsen, J.J.
Lambooy, L.H.J.
Ruitenbeek, W.
Hooymans, P.M.
van Bodegraven, A.A.
de Jong, D.J.
Source :: Journal of Clinical Pharmacology. February 2007, Vol. 47 Issue 2, p187, 5 p.
Publication Year :: 2007
Abstract: The proposed metabolic advantage of 6-thioguanine (6-TG) is the direct conversion into the pharmacologically active 6-thioguaninenucleotides (6-TGN). The authors assessed metabolic characteristics of 6-TG treatment in patients with Crohn's disease [...]

Subjects :: Drug therapy
Research
Dosage and administration
Crohn's disease -- Drug therapy -- Research
Azathioprine -- Dosage and administration -- Research
Combination drug therapy -- Research
Drug metabolism -- Research
Thioguanine -- Dosage and administration -- Research
Drug therapy, Combination -- Research

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