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[NAD.sup.+] metabolism in health and disease
- Source :
- Trends in Biochemical Sciences. Jan, 2007, Vol. 32 Issue 1, p12, 8 p.
- Publication Year :
- 2007
-
Abstract
- Nicotinamide adenine dinucleotide ([NAD.sup.+]) is both a coenzyme for hydride-transfer enzymes and a substrate for [NAD.sup.+]-consuming enzymes, which include ADP-ribose transferases, poly(ADP-ribose) polymerases, cADP-ribose synthases and sirtuins. Recent results establish protective roles for [NAD.sup.+] that might be applicable therapeutically to prevent neurodegenerative conditions and to fight Candida glabrata infection. In addition, the contribution that [NAD.sup.+] metabolism makes to lifespan extension in model systems indicates that therapies to boost [NAD.sup.+] might promote some of the beneficial effects of calorie restriction. Nicotinamide riboside, the recently discovered nucleoside precursor of [NAD.sup.+] in eukaryotic systems, might have advantages as a therapy to elevate [NAD.sup.+] without inhibiting sirtuins, which is associated with high-dose nicotinamide, or incurring the unpleasant side-effects of high-dose nicotinic acid.
- Subjects :
- Metabolism -- Analysis
NAD (Coenzyme) -- Analysis
Biological sciences
Chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 09680004
- Volume :
- 32
- Issue :
- 1
- Database :
- Gale General OneFile
- Journal :
- Trends in Biochemical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.159027575