Desmoplastic Infantile Ganglioglioma

Byline: Randall D. Craver (1), Joseph Nadell (2), James S. Nelson (1) Keywords: Key words: desmoplastic infantile ganglioglioma, microtubule associated protein-2, neuron specific B-tubulin Abstract: We present the clinical, anatomic, and laboratory findings in a 4-month-old child with desmosplastic infantile ganglioglioma. Microtubule-associated protein-2 (AP18) and neuron-specific B-tubulin (TUJ-1) were more sensitive in detecting immature neural elements than synaptophysin. Despite the immature neuroblastic component, focal intermediate proliferation indices, microinvasion, presence of secondary features (extension into Virchow Robin spaces, perineuronal satellitosis), and subtotal resection, the child has done well, with striking improvement of the magnetic resonance imaging (MRI) image, head size improvement, no tumor recurrence, and minimal neurological deficits. Author Affiliation: (1) Department of Pathology, Louisiana State University Medical Center and New Orleans Children's Hospital, 200 Henry Clay Avenue, New Orleans, LA 70118, USA , US (2) Department of Neurosurgery, New Orleans Children's Hospital, 200 Henry Clay Avenue, New Orleans, LA 70118, USA , US Article note: Received November 25, 1998 accepted February 10, 1999.