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Enolpyruvyl activation by enolpyruvylshikimate-3-phosphate synthase

Authors :
Clark, Meghann E.
Berti, Paul J.
Source :
Biochemistry. Feb 20, 2007, Vol. 46 Issue 7, p1933, 8 p.
Publication Year :
2007

Abstract

A study focuses on the enolpyruvylshikimate-3-phosphate synthase, EPSP (AroA), which is a carboxyvinyl transferase that helps in the biosynthesis of aromatic amino acid by using shikimate 3-phosphate and phosphoenolpyruvate. The analysis reveals that a large amount of catalytic power is used up by AroA for the formation of an EPSP cation, an intermediate which is a very easy target motif for inhibitor design.

Subjects

Subjects :
Phosphates -- Structure
Phosphates -- Chemical properties
Pyruvates -- Chemical properties
Pyruvates -- Structure
Enols -- Chemical properties
Enols -- Structure
Nucleophilic reactions -- Research
Biological sciences
Chemistry

Details

Language :
English
ISSN :
00062960
Volume :
46
Issue :
7
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.161230849

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