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Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage
- Source :
- Biochemistry. June 14, 1994, Vol. 33 Issue 23, p7099, 8 p.
- Publication Year :
- 1994
-
Abstract
- The rate of DNA repair is related to the rate of formation of poly(ADP-ribose) polymerase and its degradation by poly(ADP-ribose) glycohydrolase. Gamma-ray induced single-strand breaks in DNA are effectively rejoined with the help of NAD-dependent poly(ADP-ribose)polymerase automodification. The formation of poly(ADP-ribose) controls the maintenance of chromosomes and exhibits dual functional characteristics.
- Subjects :
- Ribose -- Research
DNA repair -- Research
Biological sciences
Chemistry
Subjects
Details
- ISSN :
- 00062960
- Volume :
- 33
- Issue :
- 23
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.16147694