Association of renal adenocarcinoma and BK virus nephropathy post transplantation

Byline: Joshua Yehuda Kausman (1), Gino Rene Somers (2), David Michael Francis (1), Colin Lindsay Jones (1) Keywords: Kidney transplantation; BK virus; Polyomavirus; Kidney neoplasms Abstract: While most BK virus infections are asymptomatic, immunosuppression has been associated with BK virus reactivation and impaired graft function or ureteric ulceration in renal transplant patients and hemorrhagic cystitis in bone marrow transplant patients. Oncogenicity is also postulated and this is the first report of a child with a carcinoma of the donor renal pelvis following BK virus allograft nephropathy. Removal of the primary tumor and cessation of immunosuppression led to regression of secondary tumors and a return to health. Author Affiliation: (1) Department of Nephrology, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia (2) Department of Anatomical Pathology, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia Article History: Registration Date: 23/12/2003 Received Date: 08/08/2003 Accepted Date: 12/12/2003 Online Date: 24/02/2004