The enhancement of pericentromeric cohesion association by conserved kinetochore components promotes high-fidelity chromosome segregation and is sensitive to microtubule-based tension

A new technique is developed and employed to analyze the effect of the enhancement of arm and pericentromeric cohesion in various kinetochore components on high-fidelity chromosome segregation. The analysis reveals that such cohesion is very essential for high-fidelity segregation and is also really sensitive to the kinetochore-microtubule attachments, which makes it very helpful in promoting chromosome biorientation in higher eukaryotes.