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Solution structure and cell selectivity of piscidin 1 and its analogues

Authors :
Sung-Ah Lee
Yu Kyoung Kim
Shin Saeng Lim
Wan Long Zhu
Hyunsook Ko
Song Yub Shin
Kyung-Soo Hahm
Yangmee Kim
Source :
Biochemistry. March 27, 2007, Vol. 46 Issue 12, p3653, 11 p.
Publication Year :
2007

Abstract

The effect of substituting two glycine residues, Gl[y.sup.8] and Gl[y.sup.13] with Ala or Pro on the peptide's structure and biological activities is examined to develop novel antibiotic peptides with selectivity for bacterial cells. It is demonstrated that the Gly-Pr[o.sup.8] is an excellent candidate lead compound for the development of novel antimicrobial agents.

Details

Language :
English
ISSN :
00062960
Volume :
46
Issue :
12
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.163321589