Bound sulphadimidine residues in raw fermented sausage: release under acidic conditions and bioavailability in rats

Byline: L. A. Smit (1), N. Haagsma (1), A. Ruiter (1) Keywords: Key wordsaSulphadimidine; Fermented sausage; Carbon-14-labelling; Rat; Bound residues Abstract: aSulphadimidine (SDM), a drug frequently administered to pigs, is partially converted into other compounds by processing meat to produce raw, fermented sausage. With the aid of 14.sup.C-labelled SDM, evidence was obtained that part of the radioactive matter was covalently bound to the matrix. Part of these bound residues could be released in vitro by 4M HCl at 21aadegC or by 0.024M HCl at 37aadegC. Female rats were also able to release bound SDM residues and to excrete these in their urine, in amounts approaching those obtained by treatment with 4M HCl. Both the parent compound and its main metabolite, N .sup.4-acetyl-SDM, were observed in the urine of rats. Author Affiliation: (1) Department of the Science of Food of Animal Origin, Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.175, 3508 TD Utrecht, The Netherlands, NL Article note: Received: 29 December 1997 / Revised version: 20 February 1998