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Tetrasubstituted pyrrolidines via a tandem aza-payne/hydroamination reaction

Authors :
Schomaker, Jennifer M.
Geiser, Andrea R.
Rui Huang
Borhan, Babak
Source :
Journal of the American Chemical Society. April 4, 2007, Vol. 129 Issue 13, p3794, 2 p.
Publication Year :
2007

Abstract

A mild tandem aza-Payne/hydroamination reaction of aziridinols mediated by dimethylsulfoxonium methylide is reported which yields highly functionalized pyrrolidine ring systems in one pot at room temperature. The resulting strained enamide products are potentially useful synthons for the rapid construction of densely substituted pyrrolidines and pyrrolidinones for use in natural product synthesis.

Details

Language :
English
ISSN :
00027863
Volume :
129
Issue :
13
Database :
Gale General OneFile
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
edsgcl.163673949