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Synthesis of (1R,3R,5S)-1-amino-3-(hydroxymethyl)bicyclo(3.1.0)hexane as a precursor for the synthesis of carbocyclic nucleosides
- Source :
- Journal of Organic Chemistry. Sept 9, 1994, Vol. 59 Issue 18, p5336, 7 p.
- Publication Year :
- 1994
-
Abstract
- Synthesis of (1R,3R,5S)-1-amino-3-(hydroxymethyl)bicyclo(3.1. 0)hexane from (2S,3S)-2-amino-2,3-methanoadipate involves cyclization, elimination, reduction and hydrogenation. Conversion of (R)-2-((benzyloxy)ethyl)oxiranes to (2S,3S)-2-amino-2,3-methanoadipate involves the use of lactones. The bicyclo(3.1.0)hexane functions as a precursor in the synthesis of various carbocyclic nucleosides.
Details
- ISSN :
- 00223263
- Volume :
- 59
- Issue :
- 18
- Database :
- Gale General OneFile
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.16375544