Synthesis of (1R,3R,5S)-1-amino-3-(hydroxymethyl)bicyclo(3.1.0)hexane as a precursor for the synthesis of carbocyclic nucleosides

Synthesis of (1R,3R,5S)-1-amino-3-(hydroxymethyl)bicyclo(3.1. 0)hexane from (2S,3S)-2-amino-2,3-methanoadipate involves cyclization, elimination, reduction and hydrogenation. Conversion of (R)-2-((benzyloxy)ethyl)oxiranes to (2S,3S)-2-amino-2,3-methanoadipate involves the use of lactones. The bicyclo(3.1.0)hexane functions as a precursor in the synthesis of various carbocyclic nucleosides.