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Structure of a DNA repair substrate containing an alkyl interstand cross-link at 1.65 Angstrom resolution
- Source :
- Biochemistry. April 17, 2007, Vol. 46 Issue 15, p4545, 9 p.
- Publication Year :
- 2007
-
Abstract
- The X-ray structure of a DNA duplex containing a synthetic [N.sup.4]C-ethyl-[N.sup.4]C interstrand cross-link between the cytosines of the central CpG step is determined at 1.65 Angstrom resolution. This structure reveals that the ethyl cross-link in the CpG major grooves does not significantly disrupt the B-form DNA helix.
- Subjects :
- DNA repair -- Research
Biological sciences
Chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 46
- Issue :
- 15
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.163914685