Identification of genes that interact with the sina gene in Drosophila eye development

Genetic screening of mutations that weaken the activity of sina gene in Drosophila eye development reveals nine genes whose products are crucial for normal sina activity. The Sevenless-Ras pathway signaling in R7 requires three of these genes, one of which is for the rolled locus (rl). The rl gene encodes a mitogen-induced protein kinase that is required for Ras signaling.