VLDL production is decreased to a similar extent by acute portal vs. peripheral venous insulin

Experimental analyses of the effects of hyperinsulinemia on very low density lipoprotein (VLDL), apolipoprotein (apo) B and VLDL triglyceride (TG) production in 11 healthy males reveal that hyperinsulinemia inhibits VLDL generation and plasma free fatty acid levels in the males. The inhibitory effect requires insulin but is independent of the pathway of insulin delivery, through the peripheral or portal vein. The decreases in VLDL-TG and VLDL-apoB are similar in the exogenous insulin and tolbutamide infusion studies, which also indicate that tolbutamide has no independent impact on the VLDL-TG and apoB production.