Asymmetric synthesis of ring functionalized trans-2,6-disubstituted piperidines from N-sulfinyl [delta]-amino [beta]-keto phosphonates. Total synthesis of (-)-myrtine

Asymmetric synthesis of ring functionalized trans-2,6-disubstituted piperidines from N-sulfinyl [delta]-amino [beta]-keto phosphonates was carried out. The method involves the one-pot conversion of sulfinimine-derived N-sulfinyl [delta]-amino [beta]-ketophosphonates, the stereoselective addition of organocuprates and one the one-pot dephosphorylation of the 3-phosphoryl piperidiens.