Numerical simulation on the mechanical characteristics of double-stranded DNA under axial stretching and lateral unzipping

The clustered atomistic-continuum method (CACM) comprising of the clustered atom method (CAM) and the atomistic-continuum method (ACM) based on the Newtonian transient finite element approach, is applied to analyze the mechanical features of the long-chain double stranded DNA (dsDNA) molecule under the axial stretching and lateral unzipping. It is indicated that the sequential difference can initiate the various mechanical characteristics and the dsDNA CACM model can simulate the dsDNA under different loading/boundary conditions in silico.