Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases

Authors :: Xie, Jing
Bessling, Seneca L.
Cooper, Timothy K.
Dietz, Harry C.
McCallion, Andrew S.
Fisher, Shannon
Source :: Genetics. June, 2007, Vol. 176 Issue 2, p1339, 4 p.
Publication Year :: 2007
Abstract: RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.

Subjects :: Zebra fish -- Genetic aspects
Embryo -- Genetic aspects
Helicases -- Genetic aspects
Genetic recombination -- Evaluation
Mitosis -- Evaluation
Biological sciences

Tools