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Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases
- Source :
- Genetics. June, 2007, Vol. 176 Issue 2, p1339, 4 p.
- Publication Year :
- 2007
-
Abstract
- RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.
Details
- Language :
- English
- ISSN :
- 00166731
- Volume :
- 176
- Issue :
- 2
- Database :
- Gale General OneFile
- Journal :
- Genetics
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.166751186