Lipid interaction converts prion protein to a Pr[P.sup.Sc] -like proteinase K-resistant conformation under physiological conditions

Authors :: Fei Wang
Fan Yang
Yunfei Hu
Xu Wang
Xinhe Wang
Changwen Jin
Jiyan Ma
Source :: Biochemistry. June 12, 2007, Vol. 46 Issue 23, p7045, 9 p.
Publication Year :: 2007
Abstract: The prion protein (PrP)-lipid interaction is analysed under physiological conditions using recombinant mouse PrP. It is found that PrP-lipid interaction is initiated by electrostatic contact and followed by hydrophobic interaction.

Subjects :: Proteases -- Structure
Proteases -- Chemical properties
Prions -- Structure
Prions -- Chemical properties
Proteins -- Conformation
Proteins -- Research
Biological sciences
Chemistry

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