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Oxidant stress decreases Na+/H+ antiport activity in bovine pulmonary artery endothelial cells
- Source :
- The American Journal of Physiology. Dec, 1994, Vol. 267 Issue 6, pL649, 11 p.
- Publication Year :
- 1994
-
Abstract
- Analysis of the effects of oxidant stress on the Na+/H+ antiport activity in monolayers exposed in the oxidant, tert-butyl hydroperoxide (t-BOOH), shows that oxidant stress attenuates Na+/H+ antiport activity in bovine pulmonary artery endothelial cells. Na+/H+ antiport regulates intracellular pH in these cells and t-BOOH decreases the rate of recovery from acidosis. The intracellular glutathione in these cells enable the maintenance of Na+/H+ antiport functions.
Details
- ISSN :
- 00029513
- Volume :
- 267
- Issue :
- 6
- Database :
- Gale General OneFile
- Journal :
- The American Journal of Physiology
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.16690160