Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. Possible new GSK-3[beta] therapies for bipolar disorders

Authors :: Kozikowski, Alan P.
Gaisina, Irina N.
Hongbin Yuan
Petukhov, Pavel A.
Blond, Sylvie Y.
Fedolak, Allison
Caldarone, Barbara
McGonigle, Paul
Source :: Journal of the American Chemical Society. July 4, 2007, Vol. 129 Issue 26, p8328, 5 p.
Publication Year :: 2007
Abstract: Structure-based design methods are used for designing and synthesizing a new series of 3-benzofuranyl-4-indolylmaleimides as potent and relatively selective glycogen synthase kinase-3[beta] (GSK-3[beta]) inhibitors. The analysis has demonstrated the efficacy of a GSK-3[beta] inhibitor in a novel mouse model of mania.

Subjects :: Bipolar disorder -- Drug therapy
Bipolar disorder -- Research
Phosphotransferases -- Structure
Phosphotransferases -- Chemical properties
Lithium compounds -- Structure
Lithium compounds -- Chemical properties
Glycogen -- Synthesis
Glycogen -- Research
Chemistry

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