Probing the binding site of the [A.sub.1] adenosine receptor reengineered for orthogonal recognition by tailored nucleosides

Authors :: Palaniappan, Krishnan K.
Zhan-Guo Gao
Ivanov, Andrei A.
Greaves, Rebecca
Adachi, Hayamitsu
Besada, Pedro
Hea Ok Kim
Ae Yil Kim
Seung Ah Choe
Lak Shin Jeong
Jacobson, Kenneth A.
Source :: Biochemistry. June 26, 2007, Vol. 46 Issue 25, p7437, 12 p.
Publication Year :: 2007
Abstract: A neoceptor approach is employed to analyze the binding site of the [A.sub.1] adenosine receptor, which is modified by tailored nucleosides for orthogonal recognition. The His residue is found to induce conformational changes in a ligand to activate the full spectrum of functional effects.

Subjects :: Nucleosides -- Research
Binding sites (Biochemistry) -- Research
Ligands (Biochemistry) -- Research
Biological sciences
Chemistry

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