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Probing the binding site of the [A.sub.1] adenosine receptor reengineered for orthogonal recognition by tailored nucleosides
- Source :
- Biochemistry. June 26, 2007, Vol. 46 Issue 25, p7437, 12 p.
- Publication Year :
- 2007
-
Abstract
- A neoceptor approach is employed to analyze the binding site of the [A.sub.1] adenosine receptor, which is modified by tailored nucleosides for orthogonal recognition. The His residue is found to induce conformational changes in a ligand to activate the full spectrum of functional effects.
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 46
- Issue :
- 25
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.167547084