Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression

Authors :: Schwarz, James K.
Bassing, Craig H.
Kovesdi, Imre
Datto, Michael B.
Blazing, Michael
George, Samuel
Wang, Xiao-Fan
Nevins, Joseph R.
Source :: Proceedings of the National Academy of Sciences of the United States. Jan 17, 1995, Vol. 92 Issue 2, p483, 5 p.
Publication Year :: 1995
Abstract: Overexpression of E2F1 transcription factor, using a recombinant adenovirus containing the human E2F1 gene, in mink lung epithelial cells exhibiting transforming growth factor-beta (TGF-beta)-mediated growth arrest helps assess the role of E2F1 transcription factor. E2F1 overexpression prevents growth inhibition mediated by TGF-beta. Thus, E2F activation is a downstream target for the TGF-beta-mediated cyclin-dependent kinases.

Subjects :: Genetic transcription -- Research
Gene expression -- Analysis
Growth factors -- Analysis
Science and technology

ISSN :: 00278424
Volume :: 92
Issue :: 2
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.16774435

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