Peptide binding by a fragment of calmodulin composed of EF-hands 2 and 3

The studies have shown that [Ca.sup.2+]-ligated calmodulin (CaM) encompassing EF-hands 2 and 3 (CaM2/3) are bound to a peptide representing the CaM-recognition sequence of skeletal muscle myosin light chain kinase (M13). They have highlighted the plasticity of EF-hand association and the diverse repertoire of mechanisms possible for CaM-target protein interactions.