Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase Ptp

Authors :: Soeliner, Matthew B.
Rawis, Katherine A.
Grunder, Christoph
Alber, Tom
Ellman, Jonathan A.
Source :: Journal of the American Chemical Society. August 8, 2007, Vol. 129 Issue 31, 9613-9615
Publication Year :: 2007
Abstract: The fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase B (PtpB) is being discussed. The small size of the compound imparts good selectivity to it.

Subjects :: Phosphatases -- Structure
Phosphatases -- Chemical properties
Phosphatases -- Spectra
Nuclear magnetic resonance spectroscopy -- Analysis
Tyrosine -- Structure
Tyrosine -- Chemical properties
Tyrosine -- Spectra
Chemical synthesis -- Analysis
Chemistry

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