Independent Vascular and Cognitive Risk Factors for Postoperative Delirium

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.amjmed.2007.02.026 Byline: James L. Rudolph (a)(h)(i), Richard N. Jones (b)(e)(i), Lars S. Rasmussen (c), Jeffrey H. Silverstein (d), Sharon K. Inouye (b)(e)(i), Edward R. Marcantonio (b)(e)(f)(i) Keywords: Atherosclerosis; Cognition; Delirium; Risk factors; Surgery; Tobacco; Vascular surgery Abstract: Delirium is a common, morbid, and costly syndrome that occurs frequently after surgery for atherosclerosis. We hypothesized that vascular risk factors and mildly impaired cognitive performance would independently predispose nondemented patients to develop delirium after noncardiac surgery. Author Affiliation: (a) Geriatric Research, Education, and Clinical Center, VA Boston Healthcare System, Boston, Mass. (b) Institute for Aging Research and Aging Brain Center, Hebrew SeniorLife, Boston, Mass. (c) Centre of Head and Orthopaedics, Department of Anaesthesia, Copenhagen University Hospital, Copenhagen, Denmark. (d) Departments of Anesthesiology, Surgery, and Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY. (e) Divisions of Gerontology, Beth Israel Deaconess Medical Center, Boston, Mass. (f) General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Mass. (h) Division of Aging, Brigham and Women's Hospital, Boston, Mass. (i) Department of Medicine, Harvard Medical School, Boston Mass. Article Note: (footnote) These data were collected as a result of funding from multiple sources. The authors were supported in part by National Institute of Health grants: 5 K12 AG00294-18 (Dr Rudolph), 5 P60 AG08812-14 (Drs Marcantonio and Jones), RO1AG018772-04 (Dr Silverstein), and R21AG025193 and K24AG000949 (Dr Inouye).