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Binding of TPX2 to Aurora A alters substrate and inhibitor interactions
- Source :
- Biochemistry. Sept 11, 2007, Vol. 46 Issue 36, 10287-10295
- Publication Year :
- 2007
-
Abstract
- A study reveals that while TPX2, a binding partner and activator of AurA, binding has no effect on the turnover number of AurA and does not change the reaction mechanism, it increases the binding affinity of both ATP and a peptide substrate.
- Subjects :
- ATP synthesis -- Analysis
Peptides -- Analysis
Biological sciences
Chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 46
- Issue :
- 36
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.168760315