Back to Search
Start Over
Extensive sugar modification improves triple helix forming oligonucleotide activity in vitro but reduces activity in vivo
- Source :
- Biochemistry. Sept 4, 2007, Vol. 46 Issue 35, 10222-10233
- Publication Year :
- 2007
-
Abstract
- Triple helix forming oligonucleotides (TFOs) are developed for gene targeting and their influence on bioactivity of the modifications is examined. The enhancement of TFO bioactivity has required chemical modifications that improve interaction with the specific targets while retaining selectivity against mismatched sequences.
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 46
- Issue :
- 35
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.168802043