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TRAF1-C5 as a risk locus for rheumatoid arthritis- a genomewide study

Authors :
Plenge, Robert M.
Seielstad, Mark
Padyukov, Leonid
Lee, Annette, T.
Remmers, Elaine F.
Seldin, Michael F.
Bo Ding
Liew, Anthony
Khalili, Houman
Chandrasekaran, Alamelu
Davies, Leela R. L.
Kastner, Daniel L.
Wentian Li
Tan, Andrian K. S.
Bonnard, Carine
Ong, Rick T. H.
Thalamuthu, Anbupalam
Klareskog, Lars
Pettersson, Sven
Chunyu Liu
Chao Tian
Wei V. Chen
Carulli, John P.
Gregerson, Peter K.
Beckman, Evan M.
Evan M.
Altshuler, David
Alfredsson, Lars
Criswell, Lindsey A.
Amos, Christopher I.
Source :
The New England Journal of Medicine. Sept 20, 2007, Vol. 357 Issue 12, p1199, 11 p.
Publication Year :
2007

Abstract

The article discusses a study that helps in the identification of several genetic loci, including TRAF1 (encoding tumor necrosis factor-receptor associated factor 1) and C5 (encoding complement component 5) that increase the risk for rheumatoid arthritis considerably.

Subjects

Subjects :
Tumor necrosis factor -- Research
Tumor necrosis factor -- Physiological aspects
Rheumatoid arthritis -- Risk factors
Rheumatoid arthritis -- Research
Rheumatoid arthritis -- Genetic aspects
Quantitative trait loci -- Research
Quantitative trait loci -- Physiological aspects

Details

Language :
English
ISSN :
00284793
Volume :
357
Issue :
12
Database :
Gale General OneFile
Journal :
The New England Journal of Medicine
Publication Type :
Academic Journal
Accession number :
edsgcl.169396904

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