Dissociation of DNA-histone assemblies resulting from protein side-chain functionalization

The action of photogenerated methyl radical on a DNA/histone assembly in air has resulted in dissociation of the biomolecular complex because of side-chain modifications including the conversion of lysine amines into aldehyde groups. Histone charge and the level of chromatic condensation have played a vital role in regulating gene expression and have led to protein-DNA dissociation, which has caused significant cellular effects.