Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice

Authors :: Nomiyama, Takashi
Perez-Tilve, Diego
Ogawa, Daisuke
Gizard, Florence
Zhao, Yue
Heywood, Elizabeth B.
Jones, Karrie L.
Kawamori, Ryuzo
Cassis, Lisa A.
Tschop, Matthias H.
Bruemmer, Dennis
Source :: Journal of Clinical Investigation. Oct, 2007, Vol. 117 Issue 10, p2877, 12 p.
Publication Year :: 2007
Abstract: Obesity is associated with a state of chronic, low-grade inflammation characterized by abnormal cytokine production and macrophage infiltration into adipose tissue, which may contribute to the development of insulin resistance. [...]

Subjects :: Adipose tissues -- Health aspects
Adipose tissues -- Research
Macrophages -- Research
Macrophages -- Health aspects
Obesity -- Causes of
Obesity -- Research

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