Associations with myocardial infarction of six polymorphisms selected from a three-stage genome-wide association study

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2007.06.032 Byline: Benjamin D. Horne (a), John F. Carlquist (a)(b), Joseph B. Muhlestein (a)(b), Zachary P. Nicholas (a), Jeffrey L. Anderson (a)(b) Abstract: Coronary heart disease, including its clinical manifestation, myocardial infarction (MI), is a common, complex disease with a substantive genetic component. State-of-the-art genetic epidemiology evaluates thousands of single nucleotide polymorphisms (SNPs) in association with disease cases and controls. In an independent but demographically similar population, this study tested 6 SNPs that were previously reported to be associated with MI. Author Affiliation: (a) Cardiovascular Department, LDS Hospital, Intermountain Medical Center, Salt Lake City, UT (b) Cardiology Division, Department of Internal Medicine, University of Utah, Salt Lake City, UT Article History: Received 2 February 2007; Accepted 19 June 2007 Article Note: (footnote) This study was funded by a grant (to BDH) from the Deseret Foundation, Salt Lake City, UT.