Back to Search Start Over

Benzene induces gene-duplicating but not gene-activating mutations at the glycophorin A locus in exposed humans

Authors :
Rothman, N.
Haas, R.
Hayes, R.B.
G.-L. Li
Wiemels, J.
Campleman, S.
Quintana, P.J.E.
Xi, L.-J.
Dosemeci, M.
Titenko-Holland, N.
Meyer, K.B.
Lu, W.
Zhang, L.P.
Bechtold, W.
Wang, Y.-Z.
Kolachana, P.
Yin, S.-N.
Blot, W.
Smith, M.T.
Source :
Proceedings of the National Academy of Sciences of the United States. April 25, 1995, Vol. 92 Issue 9, p4069, 5 p.
Publication Year :
1995

Abstract

In human bone marrow cells, benzene develops gene-duplicating mutations at the glycophorin A (GPA) locus. Enhanced exposure to benzene increases the cell frequency of the surface protein with double N expression (NN), but not of the surface protein with single N. Duplication of the N allele and loss of the GPA M allele produces the NN variant. The surface protein with single N allele results from gene inactivation.

Details

ISSN :
00278424
Volume :
92
Issue :
9
Database :
Gale General OneFile
Journal :
Proceedings of the National Academy of Sciences of the United States
Publication Type :
Academic Journal
Accession number :
edsgcl.17137547