Transmembrane domain of myelin protein zero can form dimmers: Possible implications for myelin construction

Study is presented to show that the myelin protein zero transmembrane (MPZ TM) domain forms stable dimers that are mediated by the glycine zipper motif. Based on this result a new mode is proposed for the MPZ adhesion structure in which dimers of tetramers form a complementary lattice that bonds adjacent layers of the myelin sheath.